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Stückelberg (Taunus)

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Stückelberg

Highest point

Elevation
510 m (1,670 ft)

Geography

Location
Hesse, Germany

Stückelberg is a Taunus mountain of Hesse, Germany.
Coordinates: 50°18′59″N 8°20′03″E / 50.31639°N 8.33417°E / 50.31639; 8.33417

This Hesse location article is a stub. You can help Wikipedia by expanding it.

v
t
e

분당오피

Collagen, type IV, alpha 1

COL4A1

Available structures

PDB
Ortholog search: PDBe RCSB

List of PDB id codes

1LI1

Identifiers

Aliases
COL4A1, HANAC, ICH, POREN1, arresten, BSVD, RATOR, collagen type IV alpha 1, collagen type IV alpha 1 chain

External IDs
MGI: 88454 HomoloGene: 20437 GeneCards: COL4A1

Genetically Related Diseases

Obesity[1]

Gene ontology

Molecular function
• extracellular matrix constituent conferring elasticity
• extracellular matrix structural constituent
• protein binding
• platelet-derived growth factor binding

Cellular component
• collagen trimer
• endoplasmic reticulum lumen
• extracellular matrix
• proteinaceous extracellular matrix
• collagen type IV trimer
• extracellular region
• basement membrane
• extracellular space

Biological process
• renal tubule morphogenesis
• epithelial cell differentiation
• blood vessel morphogenesis
• extracellular matrix organization
• brain development
• neuromuscular junction development
• angiogenesis
• retinal blood vessel morphogenesis
• basement membrane organization
• branching involved in blood vessel morphogenesis
• collagen catabolic process
• cellular response to amino acid stimulus
• collagen-activated tyrosine kinase receptor signaling pathway

Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species
Human
Mouse

Entrez

1282

12826

Ensembl

ENSG00000187498

ENSMUSG00000031502

UniProt

P02462

P02463

RefSeq (mRNA)

NM_001845
NM_001303110

NM_009931

RefSeq (protein)

NP_001290039
NP_001836

NP_034061.2
NP_034061

Location (UCSC)
Chr 13: 110.15 – 110.31 Mb
Chr 8: 11.2 – 11.31 Mb

PubMed search
[2]
[3]

Wikidata

View/Edit Human
View/Edit Mouse

Collagen alpha-1(IV) chain (COL4A1) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13.[4][5] It is ubiquitously expressed in many tissues and cell types.[6] COL4A1 is a subunit of the type IV collagen and plays a role in angiogenesis.[7] Mutations in the gene have been linked to diseases of the brain, muscle, kidney, eye, and cardiovascular system.[8][9][10][11] The COL4A1 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.[12]

Contents

1 Structure

1.1 Gene
1.2 Protein

2 Function
3 Clinical significance

3.1 Clinical Marker

4 Referenc